|
Amyloidosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
All amyloid precipitates apparent at the light microscopic level immunostained for PrP.
|
8310806 |
1993 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cellular Prion Protein as a Receptor of Toxic Amyloid-β42 Oligomers Is Important for Alzheimer's Disease.
|
31417361 |
2019 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Neuropathologically, the common denominator is a cerebral prion protein amyloidosis; however, there is significant variability in the pattern of amyloid deposition in regions of the central nervous system among reported families.
|
7767492 |
1995 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Structural and mechanistic commonalities of amyloid-β and the prion protein.
|
21862871 |
2013 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because prion protein PrP-(23-98) was recently found to polymerize into amyloid-like and proteinase K-resistant spherical aggregates in the presence of NADPH plus copper ions, we tested to determine whether calreticulin (CRT) inhibits PrP-(23-98) aggregation in vitro.
|
21821925 |
2011 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using paraffin-embedded sections, we applied histology and single- and multiple-labeling immunohistochemistry for PrP, p-tau, and Aβ to the three cases.
|
30240140 |
2018 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we have shown that NCAM1 peptide constructs carrying polycationic sequences derived from Aβ peptide (KKLVFF) and PrP protein (KKRPKP) significantly promote the S100A9 amyloid self-assembly in a concentration-dependent manner by making transient interactions with individual S100A9 molecules, perturbing its native structure and acting as catalysts.
|
31194501 |
2019 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting glutamatergic and cellular prion protein mechanisms of amyloid β-mediated persistent synaptic plasticity disruption: Longitudinal studies.
|
28390893 |
2017 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Soluble Amyloid-β oligomers (Aβo) can trigger Alzheimer disease (AD) pathophysiology by binding to cell surface cellular prion protein (PrP(C)).
|
25148681 |
2014 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prion protein amyloidosis.
|
8737929 |
1996 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association between deposition of beta-amyloid and pathological prion protein in sporadic Creutzfeldt-Jakob disease.
|
18349519 |
2008 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amyloid-beta oligomers bind with nanomolar affinity to PrP(C), but the interaction does not require the infectious PrP(Sc) conformation.
|
19242475 |
2009 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical studies showed that in addition to amyloid, these patients accumulate PrP deposits which are neither fluorescent nor birefringent when stained with thioflavin S and Congo red.
|
8939199 |
1996 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aggregation and amyloid fibril formation induced by chemical dimerization of recombinant prion protein in physiological-like conditions.
|
19710507 |
2009 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The native state of prion protein (PrP) directly inhibits formation of PrP-amyloid fibrils in vitro.
|
28373719 |
2017 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.
|
26018073 |
2015 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hereditary prion protein amyloidoses.
|
12733425 |
2003 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ultrasensitive Detection of Amyloid-β Using Cellular Prion Protein on the Highly Conductive Au Nanoparticles-Poly(3,4-ethylene dioxythiophene)-Poly(thiophene-3-acetic acid) Composite Electrode.
|
31373200 |
2019 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
FDDNP binds to PrP-amyloid in postmortem human specimens, but has not been reported in vivo in prion disease.
|
17636066 |
2007 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
For synthetic amyloid-β42, small oligomeric species showed prominent binding to PrP(C), whereas in Alzheimer's disease brains larger protein assemblies containing amyloid-β42 bound efficiently to PrP(C).
|
24519981 |
2014 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The term "prion dementia" has been proposed to replace "spongiform encephalopathy", to accommodate the existence of atypical forms of these "prion protein" (PrP) cerebral amyloidoses that may not show spongiform changes in the brain.
|
8093741 |
1993 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Alzheimer disease and the prion disorders amyloid beta-protein and prion protein amyloidoses.
|
8101988 |
1993 |
|
Amyloidosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Structural Mechanism of Barriers to Interspecies Seeding Transmissibility of Full-Length Prion Protein Amyloid.
|
31161647 |
2019 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is not understood why specific mutations in the prion protein gene (PRNP) cause cerebral amyloidosis and others cause CJD.
|
29887140 |
2018 |
|
Amyloidosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gerstmann-Sträussler-Scheinker (GSS) disease is a cerebral amyloidosis linked to mutations of the PRNP gene.
|
7954833 |
1994 |